AMINOLEBAN INFUSION PDF
Aminoleban Infusion Soln(Amino acids.): Treatment of hepatic encephalopathy in patients with acute and chronic liver diseases. Beneficial in patients unde. Condition or disease, Intervention/treatment. Hepatic Encephalopathy, Drug: Aminoleban (8% amino acids infusion). Aminoleban Infusion drug information: Dosage, Interactions.
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Aminoleban Infusion Soln
Treatment of hepatic encephalopathy in patients with acute and chronic liver diseases. Beneficial in patients under hypercatabolic state eg, surgery, trauma, sepsis and burns with evidence of negative nitrogen balance, largely owing to an increased net rate of skeletal muscle breakdown.
Typically,mL of Aminoleban is appropriately mixed with lnfusion dextrose solution and administered over 24 hrs via the central vein. The dosage may be increased or decreased depending on the patient’s age, symptoms and body weight. Patients with severe renal disorder and abnormal amino acid metabolism other than hepatic disorders. Use with care in patients with severe acidosis and those with congestive heart failure.
Rare skin eruptions or other hypersensitive reactions were reported. If such reactions occur, the solution should be discontinued. Occasional nausea and vomiting were reported. Occasional chest discomfort and palpitations were reported.
Aminoleban Infusion Soln Full Prescribing Information, Dosage & Side Effects | Philippines
Large and Acute Administration: Acidosis was reported after large and acute administration of Aminoleban. Occasional chills, fever, headache and vascular pain were reported. Concomitant use with electrolyte solutions and the administration of Aminoleban in large doses require careful monitoring of electrolyte values.
Slow IV infusion is recommended. Crystals may precipitate in a cool place. Aminoleban is an amino acid solution which was formulated based on false neurotransmitter theory Fisher’s theory for treatment of encephalopathy both in acute and ainoleban liver diseases. Infusioon formulation contains high concentration of branched-chain amino acids BCAAlow concentrations of phenylalanine, tryptophan, methionine and no tyrosine.
Hepatic encephalopathy is a neuropsychiatric syndrome that develops secondary to liver disease or to portal-systemic shunting of blood, or both.
Aminoleban Infusion Dosage, Interactions
In such a patient, plasma concentrations of aromatic amino acids phenylalanine, tyrosine, tryptophan is found to be higher than normal while the plasma concentration of BCAA leucine, isoleucine, valine is lower than normal. It was suggested that a disturbance of plasma amino acid pattern may cause a disturbance in the brain amino acid concentration.
Brain neurotransmission is then impaired by an inhibition of dopamine and noradrenaline synthesis, leading to an increase of false neurotransmitters including octopamine and phenylethanolamine.
These toxic substances are suspected to induce hepatic encephalopathy. BCAA is given to normalize the amino acid imbalance in the plasma in order to compete with AAA for an uptake into the brain. In addition, after the infusion of high BCAA solution, the ammonia concentration in the blood is also decreased mainly due to the detoxification of ammonia to form glutamine. Another unique quality of BCAA is that they are mostly metabolized in the skeletal muscle, not in the liver.
They then become good sources in providing peripheral energy. In catabolic state, BCAA play an important role in preventing the muscle protein breakdown and in promoting protein synthesis to maintain positive nitrogen balance.
Amino acids formulated in Aminoleban were readily distributed to almost all tissues after IV infusion in rat experiments. The ratio of the total amino acids in protein fractions to aminoleba chain amino acids was determined to be the highest in the brain; however, there was no specific distribution of the phenylalanine and tryptophan in the brain.
B05BA01 – amino acids ; Belongs to the class of solutions for parenteral nutrition used in I. EDD, Rx Medicine containing any amount of prohibited or regulated drugs, supplied on ordinary prescription forms with S-2 license number by a licensed PDEA prescribing physician.
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Aminoleban Infusion Dosage
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