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FMC BioPolymer claimed in a statement that the new acquisition will complement its current alginate and carrageenan businesses and. FMC chemistries help grow the world’s food, improve health, enhance foods and beverages, contribute to sustainable energy and the creation of other essential. Material Safety Data Sheet. Protanal® LF S Sodium Alginate. SDS #: B. Revision Date: Version 1. FMC BioPolymer.

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Alginate is one of the most versatile biopolymers. It is in commercial use or in advanced clinical evaluation in a range of pharmaceutical and biomedical applications, including bone regeneration and tissue bulking.

Gels, algibate, fibers and solid structures of alginate are being evaluated biopolymr use in numerous tissue-engineering applications. The best known technology is immobilization of living cells in alginate gels. Such bioreactor systems are currently being developed for the treatment of a variety of diseases.

The monomers can appear in homopolymeric blocks of consecutive G-residues G-blocksconsecutive M-residues M-blocksalternating M and G-residues MG-blocks or randomly organized blocks altinate. The relative amount of each block type varies with the origin of the alginate.

FMC BioPolymer buys Norwegian alginates

Alternating blocks form the most flexible chains and are more soluble at lower pH than the other blocks. G-blocks form stiff chain elements, and two G-blocks of more than 6 residues each form stable cross-linked junctions with divalent cations e. At low pH, protonized alginates will form acidic gels. In these gels, it is mostly the homopolymeric blocks that form the junctions, where the stability of the gel is determined by the relative content of G-blocks [7].

Determination of primary structure is today possible by NMR techniques by analyzing the spectrum using appropriate statistical considerations [8, 9]. In contrast to most other polysaccharide gels, alginate gels can develop and set at constant temperature. This unique property is particularly useful in applications involving fragile materials like cells or tissue with low tolerance for higher temperatures.

Gelling occurs when the divalent cations take part in the interchain ionic binding between guluronic acids blocks G-blocks in the polymer chain giving rise to a three dimensional network. Such binding zones between the G-blocks are often referred to as egg-boxes, and consequently alginates with a high content of G-blocks induce stronger gels.


Gels made of M-rich alginate are softer and more fragile, and may also have a lower porosity. This is due to the lower binding strength between the polymer chains and to the higher flexibilities of the molecules.

FMC Corporation

The gelling process is highly dependent on diffusion of gelling ions into the polymer network and there are essentially two main classical methods for the preparation of alginate gels: This method is most commonly used in biotechnology for immobilization of living cells in alginate gel. This method is chosen if the purpose is to create a homogenous, non-syneretic alginate macrogel to fill the space of a laginate container.

Biipolymer main difference between internal and diffusion setting is the gelling kinetics. Consequently, the gel network will also be different.

These may include, but not be limited to applications such as drug delivery, tissue engineering, cell encapsulation, and medical devices. The table below is meant to serve as a summary over some of the studies performed and the conclusions drawn from them. For sodium alginates, the parameters monitored are appearance of powder, dry matter content, intrinsic viscosity, apparent viscosity, pH, molar mass, chemical composition, ash content, endotoxins, and microbial purity.

For most applications of alginates, the molar mass molecular weight is an important parameter determining the functionality of the alginate for that specific application.

Aqueous solutions of alginates are viscous, the observed solution viscosity being dependent on molar mass, concentration of alginate, temperature, and potentially also presence of salts and other compounds in the formulation. Viscosity measurements are often used as a simple measurable parameter of changes in the molar mass of a polymer, and thereby can be used as a stability indicating parameter. Depolymerization of alginates will occur in solution and in the solid state due to a variety of mechanisms.

Ultrapure alginate

On the other hand, Holme et al. The highest stability was observed in a pH interval of 5 to 8. Increased temperature will increase the rate of depolymerization for all mechanisms mentioned above Holme et al. In vivo data on the kinetics and mechanism of depolymerization of alginates are scarce.


There are no mammalian enzymes that are active towards alginates, however, even in mammals, one must expect random depolymerization mechanisms like the ones described above to occur.

Apparent viscosity, intrinsic viscosity, and molar mass, which are all indicative measurements of depolymerization, have been observed to change significantly upon time under alginahe storage conditions.

During biopolymfr, the lid of the container should be kept closed. FMC, the FMC logo and all brand names, company names, service marks, logos and trade names of FMC or its subsidiaries, affiliates or licensors are trademarks or registered trademarks of FMC Corporation or its subsidiaries, affiliates or licensors in the U.

Gelation In contrast to most other polysaccharide gels, alginate gels can develop and set at constant temperature. Effect of sodium alginate on cell survival of V and 3T3 cells cultured in vitro Report number: In vitro cell culture 3T3 mouse fibroblasts V79 Chinese hamster Alginate products: Little or no effect on cell survival and colony-forming ability. Single dose toxicity study by the intraperitoneal route Report number: No abnormal clinical signs, normal weight increase.

Single dose toxicity study by the intravenous route Report number: Poly mannuronic acid — low molecular weight, intrinsic viscosity 6.

Ultrapure alginate – NovaMatrix

Pharmacokinetics of poly-M Report number: Poly mannuronic acid 14 C-labelled Concentration: Effect of sodium alginate on cell survival of V and 3T3 cells cultured in vitro Single dose toxicity study by the intraperitoneal route Single dose toxicity study by the intravenous route Pharmacokinetics of poly-M Report number: Previous tab Next tab.

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